关键词: ChromoTek—单克隆抗体、重组单域抗体、荧光抗体、GFP或RFP连接蛋白
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      德国ChromoTek公司成立于2008年,致力于细胞生物学和蛋白质组学的研发与研究。 产品包括单克隆抗体、重组单域抗体、荧光抗体、GFP或RFP连接蛋白等。
      默瑞(上海)生物科技有限公司是德国ChromoTek公司的中国合作伙伴和签约总代理商
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        德国ChromoTek是一家专业研发生产标签抗体的公司,利用羊驼抗体的特异性解决了传统GFP/RFP抗体分子量过大、转染表达效率低的问题,研发出分子量只有15kDa的高特异性GFP抗体。ChromoTek公司的Nano-Traps是来自于alpaca羊驼的偶联有单价矩阵基质(琼脂糖珠,磁珠以及多孔板基质)的单结构域的抗体片段(VHHS)。主要的产品有GFP-Trap/ RFP-Trap:emoji:。
ChromoTek的产品分类
一、 Nano-Trap系列:
以产品结合物为标准,包含磁珠系列和琼脂糖珠子系列,还有96板系列;
抗体结合物包括GFP Trap,RFP Trap,GST Trap,Dnmt1-Trap;Mk2-Trap;P53-Trap;Mdm4/ HdmX-Trap
二、 Booster系列:含GFP booster RFP booster;
三、 可用于HCA 实验的Chromobodies(质粒或细胞系形式);
四、 高品质抗体(标签蛋白抗体和普通抗体);
Chromotek GFP-Traps已被600多篇同行评议的近期文献引用。


    ChromoTek GmbH pioneers a new class of immunologic research tools derived from single domain camel antibodies for cell biology and proteomics. Founded in 2008 as a spin-off from the Ludwig-Maximilians University Munich (LMU) by a research team around Ulrich Rothbauer, ChromoTek has rapidly developed to become a renowned supplier of innovative reagents as well as a trusted service provider for big pharma. Our management team combines complementary skills and experiences that form a basis for sustained growth.Our mission is to develop and commercialize better tools for our customers research around the world. With a series of products and services under development, our vision is to become the most recognized leader in the fields of proteomics and live cell imaging.

         New tools for better research
 

  ChromoTek's products center around the proprietary Chromobody® technology. For that, the innovative single domain camel antibody fragments are either coupled to a matrix (Nano-Traps), to a fluorescent dye (Booster) or fused to a fluorescent protein (Chromobodies®) or are part of an assay system to study protein-protein interactions (F2H-Assay). Their extremely small size and high stability make them ideal reagents for biomolecular research and live cell assays.

  Nano-Traps (e.g. GFP-Trap®, RFP-Trap®), are routinely used in thousands of labs all over the world to pulldown tagged proteins and interaction partners thereof from cell extracts, membrane or nuclear preparations. These recombinant binding proteins allow fast, efficient and reliable analytical and preparative one-step purification of proteins for a multitude of downstream applications (Western Blot, ChIP, Mass spec etc.).

  Booster are useful to increase the fluorescence signal in various microscopy applications by attaching a stable chemical fluorescent dye to green fluorescent or red fluorescent protein tags. Their advantage is to deliver enhanced sensitivity, especially in cases where photobleaching of samples is a problem.

      In genetic fusion with a fluorescent protein, Chromobodies® are functional in living cells where they detect and visualize endogenous target structures in real time. We leverage this unique feature of Chromobodies® to bring high content, dynamic live cell imaging to a next level of performance for medium to high throughput applications (i.e. drug screening).

  

 

  

 

  In addition to Chromobody® based biosensor technology, we have developed a new F2H-Assay to directly visualize protein-protein interactions in live cells. By tethering a fluorescent bait at a defined cellular structure we generate a positional protein-protein interaction biosensor and assay for co-localization of fluorescent prey proteins in living cells. Automated image acquisition and analyses allow us to perform high throughput screens for molecules and drugs perturbing specific protein-protein interactions in the cellular environment and in real time.

  To round up our product portfolio, we offer a dedicated selection of high quality monoclonal antibodies.